Circadian and circannual variations in cord blood hematopoietic cell composition

Circadian and circannual variations in cord blood hematopoietic cell composition.

Several studies have demonstrated that cord blood (CB) unit composition is an important predictor of outcome after CB transplantation, with higher infused doses of nucleated cells (NC) or hematopoietic stem and progenitor cells being associated with faster engraftment and better overall survival. 1-3 Identification of factors predicting the hematopoiet-ic cell content of CB units is, therefore,...

Cord blood hematopoietic stem cell transplantation∗

Circadian and circannual programmes in avian migration

In migratory birds, endogenous daily (circadian) and annual (circannual) rhythms serve as biological clocks that provide the major basis for their temporal orientation. Circannual rhythms are responsible for the initiation of migration both in autumn and spring. This function of timing migrations is particularly important for birds that spend the winter close to the equator where the environmen...

Advances in Hematopoietic Stem Cell Mobilization and Peripheral Blood Stem Cell Transplantation

Hematopoietic stem/progenitor cells (HSPCs) which give rise to different blood cell types are present within the bone marrow microenvironment, especially in flat bones such as skull, vertebrae, pelvis and chest. Interacting factors such as stromal derived factor-1/CXCR4, very late antigen-4/vascular cell adhesion molecule-1, Lymphocyte function-associated antigen-1/ intercellular adhesion molec...

Nanofiber Expansion of Umbilical Cord Blood Hematopoietic Stem Cells

Background The aim of this study was the ex vivo expansion of Umbilical Cord Blood hematopoietic stem cells on biocompatible nanofiber scaffolds. Materials and Methods CD133+ hematopoietic stem cells were separated from umbilical cord blood using MidiMacs (positive selection) system by means of monocolonal antibody CD133 (microbeads) subsequently, flowcytometry method was done to asses...